IRS2

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, IRS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,843 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IRS2-associated GO terms across cancer lineages are Negative regulation of long-chain fatty acid import across plasma membrane, Negative regulation of long-chain fatty acid import into cell, and Regulation of glucan biosynthetic process. Each is linked with IRS2 in more than 9 cancer types. Because this analysis shows association rather than direction, both IRS2-to-partner and partner-to-IRS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS2→partner) and Y-score (partner→IRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_MyelomaNegative regulation of long-chain fatty acid import across plasma membrane →-0.171-1.153<.001<.001310
BLOOD_MyelomaNegative regulation of long-chain fatty acid import into cell →-0.171-1.153<.001<.001310
LUNG_SCLCRegulation of glucan biosynthetic process →+0.072+1.581<.001<.001210
LUNG_SCLCRegulation of glycogen biosynthetic process →+0.072+1.581<.001<.001210
LUNG_SCLCPositive regulation of glycogen metabolic process →+0.074+1.392<.001<.00139
UPPER_AERODIGESTIVE_TRACTEstablishment of protein localization to endoplasmic reticulum →+0.101+0.882<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,843 associations by consensus.

Exploration