Across TCGA cell cohorts, IRS2 mutation is significantly associated with the RNA expression of many other genes, with 1,141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRS2-associated genes across cancer lineages are OR13C5, COX8C, and C1orf146. Each is linked with IRS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRS2-to-partner and partner-to-IRS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS2→partner) and Y-score (partner→IRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR13C5 →	+0.023	+5.000	<.001	.005	3	2
URINARY_TRACT	COX8C →	+0.094	+4.217	<.001	.005	3	2
OVARY	C1orf146 →	+0.023	+2.865	.004	.004	3	2
SKIN	CYP2A13 →	+0.027	+3.240	.002	.004	3	2
BLOOD_Lymphoma	APOC3 →	+0.206	+3.714	<.001	.006	3	2
LARGE_INTESTINE	CENPM →	+0.625	+2.364	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,141 associations by consensus.

Exploration

IRS2 survival (RNA) · tumor vs normal (RNA) · all IRS2 data types