IRS1

Across TCGA pan-cancer cohorts, IRS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IRS1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IRS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IRS1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where IRS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.308	1.000	.001	22	view →
PDAC	DFS	Quartile	II,III,IV	0.903	0.561	.002	18	view →
LSCC	DFS	Median	All	0.701	0.891	.011	8	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.892	.013	5	view →
UCEC	OS	Quartile	III,IV	0.329	1.000	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IRS1–LUAD (OS)

Open the LUAD breakdown →