IRS1

Across TCGA pan-cancer cohorts, IRS1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IRS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IRS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IRS1 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

HNSC, PDAC, and CCRCC are the cancer types where IRS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IRS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.581	<.001	11	view →
PDAC	Male	All	+0.430	<.001	8	view →
CCRCC	All	All	−0.269	<.001	5	view →
LUAD	All	All	−0.126	.003	5	view →
OV	All	All	−0.800	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IRS1–HNSC

Open the HNSC breakdown →