IRS1

Across TCGA patient cohorts, IRS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,436 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IRS1-associated proteins across cancer lineages are IRS1_S1078, IRS1_S330, and IRS1_S374. Each is linked with IRS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IRS1-to-partner and partner-to-IRS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRS1 versus IRS1_S1078 in BRCA, with a Pearson correlation of 0.75.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS1→partner) and Y-score (partner→IRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRS1_S1078 →	+1.328	+1.819	<.001	<.001	3	8
BRCA	IRS1_S330 →	+1.622	+2.274	<.001	<.001	3	8
BRCA	IRS1_S374 →	+1.118	+2.257	<.001	<.001	3	8
BRCA	IRS1_S531 →	+1.498	+1.571	<.001	<.001	3	8
BRCA	IRS1_T453 →	+0.906	+1.712	<.001	<.001	3	8
UCEC	IRS1_S1101 →	+1.227	+1.740	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,436 associations by consensus.

IRS1 vs IRS1_S1078 — BRCA

Explore this scatter interactively →