IRS1

Across TCGA patient cohorts, IRS1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,165 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IRS1-associated genes across cancer lineages are EDA2R, PRSS23, and SFXN3. Each is linked with IRS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both IRS1-to-partner and partner-to-IRS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRS1 versus EDA2R in UCEC, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS1→partner) and Y-score (partner→IRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EDA2R →	+1.007	+0.380	.005	.002	2	6
BRCA	PRSS23 →	+1.508	+0.482	<.001	.005	2	6
OV	SFXN3 →	+0.742	+0.441	.001	<.001	3	5
BRCA	CDC25A →	-0.810	-0.456	<.001	.002	3	5
UCEC	TIMP3 →	+1.572	+0.525	<.001	<.001	3	4
LSCC	SYDE1 →	+0.739	+0.528	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,165 associations by consensus.

IRS1 vs EDA2R — UCEC

Explore this scatter interactively →