IRS1

Across TCGA patient cohorts, IRS1 mutation is significantly associated with the RNA expression of many other genes, with 6,326 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRS1-associated genes across cancer lineages are RRM2, TIPIN, and RAN. Each is linked with IRS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IRS1-to-partner and partner-to-IRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RRM2 grouped by IRS1-low versus IRS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS1→partner) and Y-score (partner→IRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRM2 →	+1.001	+2.321	<.001	<.001	3	5
UCEC	TIPIN →	+0.605	+2.606	<.001	<.001	3	5
UCEC	RAN →	+0.481	+2.124	<.001	<.001	3	5
UCEC	ADAM33 →	-0.646	-2.195	.003	.001	3	4
UCEC	HAUS1 →	+0.587	+1.710	<.001	<.001	3	4
UCEC	SKA1 →	+0.952	+2.595	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,326 associations by consensus.

RRM2 by IRS1 expression — UCEC

Explore this box plot interactively →