IRS1

Across TCGA patient cohorts, IRS1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRS1-associated genes across cancer lineages are 4E-BP1, Cyclin-E2, and PKC-a_pS657. Each is linked with IRS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both IRS1-to-partner and partner-to-IRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by IRS1-low versus IRS1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS1→partner) and Y-score (partner→IRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.733	+2.820	<.001	.035	3	3
COAD	Cyclin-E2 →	+0.228	+2.832	.023	.034	2	4
BLCA	PKC-a_pS657 →	-0.353	-2.999	.028	.035	3	3
COAD	ATM →	-0.824	-3.459	<.001	.005	2	4
UCEC	Caspase-7-cleavedD198 →	+0.438	+1.678	.016	.019	3	3
UCEC	Cyclin-B1 →	+0.549	+1.700	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

4E-BP1 by IRS1 expression — LUAD

Explore this box plot interactively →