IRS1

Across TCGA cell cohorts, IRS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,516 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRS1-associated GO terms across cancer lineages are Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, Positive regulation of epithelial cell migration, and Positive regulation of cell-substrate junction organization. Each is linked with IRS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IRS1-to-partner and partner-to-IRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway grouped by IRS1-low versus IRS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS1→partner) and Y-score (partner→IRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.054	+1.944	.001	.001	3	10
SKIN	Positive regulation of epithelial cell migration →	+0.074	+1.396	<.001	<.001	3	10
SKIN	Positive regulation of cell-substrate junction organization →	+0.089	+1.097	<.001	<.001	3	9
BREAST	Regulation of mitotic cytokinetic process →	+0.120	+1.295	<.001	.003	3	9
BREAST	Positive regulation of mitotic cytokinetic process →	+0.120	+1.295	<.001	.003	3	9
BREAST	Regulation of cytokinetic process →	+0.120	+1.295	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,516 associations by consensus.

Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway by IRS1 expression — LUNG_NSCLC_LUSC

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