IRGQ

Across TCGA patient cohorts, IRGQ RNA expression is significantly associated with the protein abundance of many other proteins, with 15,956 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IRGQ-associated proteins across cancer lineages are SOX4_S354, PSMB10, and SAE1. Each is linked with IRGQ in more than 5 cancer types. Because this analysis shows association rather than direction, both IRGQ-to-partner and partner-to-IRGQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRGQ versus SOX4_S354 in GBM, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGQ→partner) and Y-score (partner→IRGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX4_S354 →	+1.276	+0.441	<.001	.005	3	6
GBM	PSMB10 →	-0.465	-0.470	<.001	<.001	3	6
GBM	SAE1 →	+0.348	+0.378	<.001	<.001	3	5
GBM	TRIM28 →	+0.395	+0.419	<.001	<.001	3	5
UCEC	NMI →	-0.438	-0.427	.001	.002	3	5
GBM	ARHGAP35 →	+0.338	+0.443	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,956 associations by consensus.

IRGQ vs SOX4_S354 — GBM

Explore this scatter interactively →