IRGQ

Across TCGA patient cohorts, IRGQ protein abundance is significantly associated with the RNA expression of many other genes, with 8,400 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IRGQ-associated genes across cancer lineages are SMG9, HNRNPUL1, and CADM4. Each is linked with IRGQ in more than 6 cancer types. Because this analysis shows association rather than direction, both IRGQ-to-partner and partner-to-IRGQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRGQ versus SMG9 in OV, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGQ→partner) and Y-score (partner→IRGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMG9 →	+0.875	+0.366	<.001	<.001	3	7
OV	HNRNPUL1 →	+0.746	+0.425	.001	<.001	3	6
HNSC	CADM4 →	+1.143	+0.259	<.001	<.001	3	6
LUAD	ZNF45 →	+0.565	+0.351	<.001	<.001	3	6
OV	ZNF225 →	+0.459	+0.285	<.001	<.001	3	6
OV	GSK3A →	+0.855	+0.470	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,400 associations by consensus.

IRGQ vs SMG9 — OV

Explore this scatter interactively →