IRGQ

Across TCGA patient cohorts, IRGQ mutation is significantly associated with the RNA expression of many other genes, with 469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRGQ-associated genes across cancer lineages are MIR6806, PLEKHA4, and TUBG1. Each is linked with IRGQ in more than 2 cancer types. Because this analysis shows association rather than direction, both IRGQ-to-partner and partner-to-IRGQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6806 grouped by IRGQ-low versus IRGQ-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGQ→partner) and Y-score (partner→IRGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6806 →	+0.508	+2.824	.001	.009	3	2
UCEC	PLEKHA4 →	-1.337	-3.700	<.001	.001	3	2
UCEC	TUBG1 →	+0.649	+3.475	.002	.002	3	2
UCEC	MIR6858 →	+0.741	+2.652	.006	<.001	3	2
PRAD	EXTL2P1 →	+0.077	+5.336	<.001	.002	3	2
PRAD	ZNF519P1 →	+0.034	+3.865	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 469 associations by consensus.

MIR6806 by IRGQ expression — CESC

Explore this box plot interactively →