IRGQ

Across TCGA patient cohorts, IRGQ mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IRGQ-associated genes across cancer lineages are CMP, Myocytes, and aDC. Each is linked with IRGQ in more than 2 cancer types. Because this analysis shows association rather than direction, both IRGQ-to-partner and partner-to-IRGQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by IRGQ-low versus IRGQ-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGQ→partner) and Y-score (partner→IRGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CMP →	+0.036	+2.659	.031	.015	3	3
UCEC	Myocytes →	+0.040	+3.016	.008	.019	2	3
SKCM	aDC →	-0.110	-3.163	.039	.020	3	1
SKCM	pro B-cells →	+0.119	+3.201	.012	.010	3	1
UCEC	pDC →	+0.050	+3.032	.027	.018	3	1
SKCM	CLP →	+0.146	+3.189	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CMP by IRGQ expression — SKCM

Explore this box plot interactively →