IRGQ

Across TCGA cell cohorts, IRGQ RNA expression is significantly associated with the go_rna of many other GO terms, with 3,299 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRGQ-associated GO terms across cancer lineages are Macroautophagy, Substrate localization to autophagosome, and Vacuole organization. Each is linked with IRGQ in more than 14 cancer types. Because this analysis shows association rather than direction, both IRGQ-to-partner and partner-to-IRGQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by IRGQ-low versus IRGQ-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGQ→partner) and Y-score (partner→IRGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Macroautophagy →	+0.080	+0.806	.001	.004	2	15
SKIN	Substrate localization to autophagosome →	+0.102	+0.585	<.001	<.001	3	14
BONE	Vacuole organization →	+0.067	+1.142	<.001	<.001	3	14
OESOPHAGUS	Golgi vesicle transport →	+0.105	+0.557	.002	.008	3	14
LARGE_INTESTINE	Autophagosome organization →	+0.060	+0.546	<.001	<.001	3	13
KIDNEY	Negative regulation of calcium ion export across plasma membrane →	+0.066	+0.565	.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

Macroautophagy by IRGQ expression — STOMACH

Explore this box plot interactively →