IRGQ

Across TCGA cell cohorts, IRGQ mutation is significantly associated with the RNA expression of many other genes, with 357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRGQ-associated genes across cancer lineages are OR51F1, GFRA4, and KRTAP21-1. Each is linked with IRGQ in more than 1 cancer types. Because this analysis shows association rather than direction, both IRGQ-to-partner and partner-to-IRGQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51F1 grouped by IRGQ-low versus IRGQ-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGQ→partner) and Y-score (partner→IRGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR51F1 →	+0.116	+5.357	<.001	.003	3	2
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
LUNG_SCLC	KRTAP21-1 →	+0.045	+4.643	<.001	.004	3	1
LARGE_INTESTINE	SGSM3 →	+0.677	+3.212	.007	.006	3	1
LARGE_INTESTINE	UBXN8 →	+0.957	+3.212	<.001	.006	3	1
LARGE_INTESTINE	BAG2 →	+0.936	+3.212	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 357 associations by consensus.

OR51F1 by IRGQ expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →