IRGC

Across TCGA patient cohorts, IRGC RNA expression is significantly associated with the go_rna of many other GO terms, with 6,908 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IRGC-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of double-strand break repair via homologous recombination, and Positive regulation of double-strand break repair. Each is linked with IRGC in more than 23 cancer types. Because this analysis shows association rather than direction, both IRGC-to-partner and partner-to-IRGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by IRGC-low versus IRGC-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGC→partner) and Y-score (partner→IRGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of DNA repair →	+0.072	+0.143	<.001	.005	2	24
ESCA	Positive regulation of double-strand break repair via homologous recombination →	+0.079	+0.148	<.001	.003	2	22
ESCA	Positive regulation of double-strand break repair →	+0.074	+0.135	<.001	.006	1	23
STAD	Regulation of DNA-templated transcription elongation →	+0.063	+0.126	<.001	<.001	3	21
STAD	Maintenance of cell number →	+0.052	+0.123	<.001	<.001	3	20
STAD	Macromolecule methylation →	+0.057	+0.140	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,908 associations by consensus.

Positive regulation of DNA repair by IRGC expression — ESCA

Explore this box plot interactively →