IRGC

Across TCGA patient cohorts, IRGC mutation is significantly associated with the RNA expression of many other genes, with 1,371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRGC-associated genes across cancer lineages are ZPR1, WRAP73, and ALMS1-IT1. Each is linked with IRGC in more than 3 cancer types. Because this analysis shows association rather than direction, both IRGC-to-partner and partner-to-IRGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZPR1 grouped by IRGC-low versus IRGC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGC→partner) and Y-score (partner→IRGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZPR1 →	+0.405	+2.243	.008	.006	3	3
UCEC	WRAP73 →	+0.349	+3.365	.009	.004	3	3
SKCM	ALMS1-IT1 →	+0.424	+2.748	.003	.002	2	4
UCEC	ZW10 →	+0.614	+2.949	.002	<.001	3	3
CESC	RN7SKP245 →	+0.130	+5.812	<.001	.003	3	2
CESC	MRPL32P1 →	+0.171	+6.569	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,371 associations by consensus.

ZPR1 by IRGC expression — UCEC

Explore this box plot interactively →