IRGC

Across TCGA patient cohorts, IRGC mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRGC-associated genes across cancer lineages are IGFBP2, AMPK_pT172, and 4E-BP1_pT37_T46. Each is linked with IRGC in more than 1 cancer types. Because this analysis shows association rather than direction, both IRGC-to-partner and partner-to-IRGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by IRGC-low versus IRGC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGC→partner) and Y-score (partner→IRGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.820	-2.584	.006	.011	3	1
UCEC	AMPK_pT172 →	+0.394	+3.169	.040	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.429	-2.986	.014	.035	3	1
UCEC	MEK1 →	+0.489	+2.584	.004	.011	1	1
UCEC	p62 Lck ligand →	+0.578	+2.584	<.001	.011	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

IGFBP2 by IRGC expression — UCEC

Explore this box plot interactively →