IRGC

Across TCGA cell cohorts, IRGC mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRGC-associated genes across cancer lineages are PROP1, ZCCHC2, and ST6GAL2. Each is linked with IRGC in more than 1 cancer types. Because this analysis shows association rather than direction, both IRGC-to-partner and partner-to-IRGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by IRGC-low versus IRGC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRGC→partner) and Y-score (partner→IRGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.020	+3.289	.001	.009	3	2
LARGE_INTESTINE	ZCCHC2 →	+1.155	+3.067	<.001	.009	3	1
LARGE_INTESTINE	ST6GAL2 →	+0.802	+2.839	<.001	.004	3	1
LARGE_INTESTINE	CHMP7 →	+0.823	+3.064	.004	.009	3	1
LARGE_INTESTINE	FAM124A →	+0.789	+3.295	<.001	.006	3	1
LARGE_INTESTINE	ATP5F1A →	+0.894	+3.082	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PROP1 by IRGC expression — BLOOD_Leukemia

Explore this box plot interactively →