Across TCGA patient cohorts, IRF9 protein abundance is significantly associated with the RNA expression of many other genes, with 5,598 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IRF9-associated genes across cancer lineages are OAS2, IFIH1, and STAT1. Each is linked with IRF9 in more than 9 cancer types. Because this analysis shows association rather than direction, both IRF9-to-partner and partner-to-IRF9 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF9→partner) and Y-score (partner→IRF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OAS2 →	+1.465	+0.486	<.001	<.001	3	10
BRCA	IFIH1 →	+1.261	+0.478	<.001	<.001	3	10
BRCA	STAT1 →	+1.279	+0.521	<.001	<.001	3	10
GBM	GBP1 →	+1.330	+0.515	<.001	<.001	3	10
LSCC	IFIT3 →	+1.524	+0.474	<.001	<.001	3	10
BRCA	IFI6 →	+1.792	+0.396	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,598 associations by consensus.

Exploration

IRF9 survival (RNA) · tumor vs normal (RNA) · all IRF9 data types