Across TCGA patient cohorts, IRF9 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF9-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and C-Raf_pS338. Each is linked with IRF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF9-to-partner and partner-to-IRF9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF9→partner) and Y-score (partner→IRF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.327	-2.449	.005	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.720	+2.341	.007	.019	3	1
UCEC	C-Raf_pS338 →	-0.085	-2.950	.020	.036	3	1
UCEC	p27_pT198 →	+0.133	+2.000	.005	.032	2	1
UCEC	MSH2 →	-0.310	-2.000	.002	.032	1	1
UCEC	MSH6 →	-0.464	-2.000	.001	.032	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

IRF9 survival (RNA) · tumor vs normal (RNA) · all IRF9 data types