Across TCGA cell cohorts, IRF9 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRF9-associated genes across cancer lineages are CCDC70, APOA5, and IRX4. Each is linked with IRF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF9-to-partner and partner-to-IRF9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF9→partner) and Y-score (partner→IRF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC70 →	+0.117	+2.774	<.001	.006	3	2
BLOOD_Leukemia	APOA5 →	+0.031	+2.774	<.001	.006	3	1
BLOOD_Leukemia	IRX4 →	+0.125	+2.884	<.001	.009	3	1
BLOOD_Leukemia	MAGEB4 →	+0.026	+3.121	<.001	.003	3	1
BLOOD_Leukemia	NRG2 →	+0.654	+3.477	.006	.009	3	1
BLOOD_Leukemia	TRAT1 →	+1.912	+3.754	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

IRF9 survival (RNA) · tumor vs normal (RNA) · all IRF9 data types