IRF8

Across TCGA patient cohorts, IRF8 protein abundance is significantly associated with the RNA expression of many other genes, with 14,606 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF8-associated genes across cancer lineages are WDFY4, CD4, and PLCB2. Each is linked with IRF8 in more than 6 cancer types. Because this analysis shows association rather than direction, both IRF8-to-partner and partner-to-IRF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF8 versus WDFY4 in LSCC, with a Pearson correlation of 0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF8→partner) and Y-score (partner→IRF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDFY4 →	+1.189	+0.646	<.001	<.001	3	7
LSCC	CD4 →	+0.909	+0.575	<.001	<.001	3	6
UCEC	PLCB2 →	+0.814	+0.267	<.001	.005	3	6
BRCA	LGALS9 →	+0.801	+0.352	.001	.002	3	6
BRCA	CD7 →	+0.920	+0.448	<.001	<.001	3	6
LSCC	CIITA →	+1.041	+0.534	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,606 associations by consensus.

IRF8 vs WDFY4 — LSCC

Explore this scatter interactively →