IRF8

Across TCGA patient cohorts, IRF8 protein abundance is significantly associated with the protein abundance of many other proteins, with 21,032 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF8-associated proteins across cancer lineages are ANKRD44, WAS, and INPP5D_S971. Each is linked with IRF8 in more than 6 cancer types. Because this analysis shows association rather than direction, both IRF8-to-partner and partner-to-IRF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF8 versus ANKRD44 in LSCC, with a Pearson correlation of 0.89.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF8→partner) and Y-score (partner→IRF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANKRD44 →	+0.560	+0.688	<.001	<.001	3	7
LSCC	WAS →	+0.567	+0.684	<.001	<.001	3	7
LSCC	INPP5D_S971 →	+0.660	+0.468	<.001	<.001	3	6
UCEC	AOAH →	+0.553	+0.315	<.001	<.001	3	6
LSCC	IKZF1 →	+0.822	+0.687	<.001	<.001	3	6
LSCC	IL16 →	+0.784	+0.652	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,032 associations by consensus.

IRF8 vs ANKRD44 — LSCC

Explore this scatter interactively →