IRF8

Across TCGA patient cohorts, IRF8 mutation is significantly associated with the RNA expression of many other genes, with 1,999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF8-associated genes across cancer lineages are CENPH, FGD5, and EME1. Each is linked with IRF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRF8-to-partner and partner-to-IRF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPH grouped by IRF8-low versus IRF8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF8→partner) and Y-score (partner→IRF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CENPH →	+0.585	+1.925	.004	.009	3	2
UCEC	FGD5 →	-0.551	-2.486	.002	.001	3	2
UCEC	EME1 →	+0.527	+1.949	.001	.001	3	2
UCEC	FANCC →	+0.369	+2.032	.003	.004	3	2
UCEC	CHAF1B →	+0.641	+2.643	<.001	<.001	3	2
UCEC	NAE1 →	+0.440	+1.652	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,999 associations by consensus.

CENPH by IRF8 expression — SKCM

Explore this box plot interactively →