IRF8

Across TCGA cell cohorts, IRF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,926 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IRF8-associated GO terms across cancer lineages are Follicular B cell differentiation, Plasmacytoid dendritic cell activation, and Synaptic vesicle targeting. Each is linked with IRF8 in more than 16 cancer types. Because this analysis shows association rather than direction, both IRF8-to-partner and partner-to-IRF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Follicular B cell differentiation grouped by IRF8-low versus IRF8-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF8→partner) and Y-score (partner→IRF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Follicular B cell differentiation →	+1.898	+3.301	<.001	<.001	3	17
BLOOD_Myeloma	Plasmacytoid dendritic cell activation →	-0.306	-2.806	<.001	<.001	3	15
STOMACH	Synaptic vesicle targeting →	+0.197	+2.397	<.001	<.001	3	6
STOMACH	Regulation of antigen processing and presentation of peptide antigen via MHC class II →	+1.244	+2.037	.006	.002	3	6
BLOOD_Lymphoma	Regulation of atrial cardiac muscle cell membrane repolarization →	-0.282	-2.700	<.001	<.001	3	6
LIVER	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.111	+1.360	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,926 associations by consensus.

Follicular B cell differentiation by IRF8 expression — LARGE_INTESTINE

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