Across TCGA pan-cancer cohorts, IRF7 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IRF7 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IRF7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IRF7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC and LSCC are the cancer types where IRF7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.437	.028	7	view →
LSCC	DFS	Tertile	All	1.000	0.495	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IRF7 tumor-vs-normal RNA expression · all IRF7 data types