Across TCGA cell cohorts, IRF7 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRF7-associated genes across cancer lineages are OR10K1, PPIAL4D, and FAM205A. Each is linked with IRF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF7-to-partner and partner-to-IRF7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF7→partner) and Y-score (partner→IRF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10K1 →	+0.340	+3.556	.003	.001	3	2
BLOOD_Leukemia	PPIAL4D →	+0.127	+3.954	<.001	.002	3	2
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
BLOOD_Lymphoma	ADAM18 →	+0.419	+4.321	<.001	.002	3	1
BLOOD_Leukemia	VSX1 →	+0.462	+4.083	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Exploration

IRF7 survival (RNA) · tumor vs normal (RNA) · all IRF7 data types