IRF6

Across TCGA patient cohorts, IRF6 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,935 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF6-associated proteins across cancer lineages are IRF6_S47, RAB25, and PPP2R5A. Each is linked with IRF6 in more than 5 cancer types. Because this analysis shows association rather than direction, both IRF6-to-partner and partner-to-IRF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF6 versus IRF6_S47 in OV, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF6→partner) and Y-score (partner→IRF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRF6_S47 →	+1.173	+0.877	.002	.002	3	6
LUAD	RAB25 →	+0.789	+0.900	<.001	<.001	3	5
OV	PPP2R5A →	+0.476	+0.932	<.001	.001	3	5
COAD	PKP4 →	+0.392	+0.455	.001	<.001	3	5
GBM	PLEKHA6 →	+0.505	+0.513	.001	<.001	3	5
BRCA	ARHGAP25 →	-0.433	-0.624	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,935 associations by consensus.

IRF6 vs IRF6_S47 — OV

Explore this scatter interactively →