IRF6

Across TCGA patient cohorts, IRF6 protein abundance is significantly associated with the RNA expression of many other genes, with 12,982 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF6-associated genes across cancer lineages are NCKAP1L, GPR65, and C1orf162. Each is linked with IRF6 in more than 6 cancer types. Because this analysis shows association rather than direction, both IRF6-to-partner and partner-to-IRF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF6 versus NCKAP1L in OV, with a Pearson correlation of -0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF6→partner) and Y-score (partner→IRF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NCKAP1L →	-1.166	-0.598	<.001	<.001	3	7
OV	GPR65 →	-0.751	-0.470	<.001	<.001	3	7
OV	C1orf162 →	-0.770	-0.573	<.001	<.001	3	7
HNSC	C1orf74 →	+0.615	+0.390	<.001	<.001	3	7
OV	BTK →	-0.859	-0.494	<.001	<.001	3	6
HNSC	RASSF4 →	-0.622	-0.407	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,982 associations by consensus.

IRF6 vs NCKAP1L — OV

Explore this scatter interactively →