IRF6

Across TCGA patient cohorts, IRF6 mutation is significantly associated with the RNA expression of many other genes, with 2,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF6-associated genes across cancer lineages are LINC00708, BAG3, and SUPV3L1. Each is linked with IRF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRF6-to-partner and partner-to-IRF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00708 grouped by IRF6-low versus IRF6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF6→partner) and Y-score (partner→IRF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC00708 →	+0.045	+5.418	<.001	.005	3	2
UCEC	BAG3 →	+0.799	+3.971	<.001	<.001	3	2
UCEC	SUPV3L1 →	+0.409	+2.332	.001	<.001	3	2
UCEC	CPSF4 →	+0.334	+1.936	.008	.003	3	2
UCEC	MON1A →	+0.406	+3.818	<.001	<.001	3	2
UCEC	POC1A →	+0.503	+2.338	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,061 associations by consensus.

LINC00708 by IRF6 expression — CESC

Explore this box plot interactively →