IRF6

Across TCGA patient cohorts, IRF6 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF6-associated genes across cancer lineages are PCNA, C-Raf, and FoxM1. Each is linked with IRF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF6-to-partner and partner-to-IRF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by IRF6-low versus IRF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF6→partner) and Y-score (partner→IRF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.262	+2.502	.001	.002	3	2
UCEC	C-Raf →	+0.193	+2.584	<.001	.010	3	2
SKCM	FoxM1 →	+0.297	+2.459	<.001	.017	3	2
SKCM	p90 RSK →	+0.225	+3.169	.013	.017	3	2
SKCM	YAP_pS127 →	-0.387	-3.304	.012	.009	3	2
LUSC	VEGFR2 →	+0.509	+3.197	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PCNA by IRF6 expression — UCEC

Explore this box plot interactively →