IRF6

Across TCGA cell cohorts, IRF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,150 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IRF6-associated GO terms across cancer lineages are Regulation of inner ear receptor cell differentiation, Cell-cell adhesion mediated by cadherin, and Regulation of mechanoreceptor differentiation. Each is linked with IRF6 in more than 11 cancer types. Because this analysis shows association rather than direction, both IRF6-to-partner and partner-to-IRF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of inner ear receptor cell differentiation grouped by IRF6-low versus IRF6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF6→partner) and Y-score (partner→IRF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of inner ear receptor cell differentiation →	+1.290	+3.298	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cell-cell adhesion mediated by cadherin →	+0.204	+1.755	.001	.006	3	12
LUNG_SCLC	Regulation of mechanoreceptor differentiation →	+1.290	+3.298	<.001	<.001	3	12
STOMACH	NMDA selective glutamate receptor signaling pathway →	+0.347	+3.235	<.001	<.001	3	11
URINARY_TRACT	Serotonin secretion →	+1.693	+4.374	<.001	<.001	3	11
URINARY_TRACT	Serotonin production involved in inflammatory response →	+1.693	+4.374	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,150 associations by consensus.

Regulation of inner ear receptor cell differentiation by IRF6 expression — LUNG_SCLC

Explore this box plot interactively →