IRF6

Across TCGA cell cohorts, IRF6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible IRF6-associated genes across cancer lineages are SPATA48, PRM1, and KRTAP11-1. Each is linked with IRF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF6-to-partner and partner-to-IRF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by IRF6-low versus IRF6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF6→partner) and Y-score (partner→IRF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPATA48 →	+0.013	+5.807	<.001	.001	3	1
OVARY	PRM1 →	+0.078	+5.196	<.001	.005	3	1
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
CNS	TMIGD1 →	+0.039	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SPATA48 by IRF6 expression — OVARY

Explore this box plot interactively →