IRF5

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IRF5 protein abundance is significantly associated with the RNA expression of many other genes, with 14,235 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IRF5-associated genes across cancer lineages are TLR8, LILRB1, and CD33. Each is linked with IRF5 in more than 8 cancer types. Because this analysis shows association rather than direction, both IRF5-to-partner and partner-to-IRF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF5 versus TLR8 in UCEC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF5→partner) and Y-score (partner→IRF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECTLR8 →+1.180+0.569<.001<.00139
GBMLILRB1 →+1.104+0.469<.001<.00139
GBMCD33 →+0.913+0.453<.001<.00139
GBMBTK →+1.042+0.478<.001<.00139
GBMMS4A6A →+1.402+0.395<.001<.00139
BRCASLC15A3 →+0.976+0.337<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 14,235 associations by consensus.

IRF5 vs TLR8 — UCEC

Per-sample scatter of IRF5 vs TLR8 in UCEC (Pearson r = 0.47).

Explore this scatter interactively →

Exploration