IRF5

Across TCGA patient cohorts, IRF5 mutation is significantly associated with the RNA expression of many other genes, with 1,594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF5-associated genes across cancer lineages are RNA5SP113, PSAT1P4, and RN7SL191P. Each is linked with IRF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF5-to-partner and partner-to-IRF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP113 grouped by IRF5-low versus IRF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF5→partner) and Y-score (partner→IRF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP113 →	+0.306	+2.418	<.001	.006	3	2
UCEC	PSAT1P4 →	+0.094	+1.563	.007	.002	3	2
UCEC	RN7SL191P →	+0.116	+1.966	<.001	.005	3	2
HNSC	RNU6-362P →	+0.368	+7.954	<.001	.008	3	2
THCA	TTTY20 →	+0.298	+7.962	<.001	.007	3	1
THCA	FAM197Y6 →	+0.009	+7.962	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,594 associations by consensus.

RNA5SP113 by IRF5 expression — UCEC

Explore this box plot interactively →