IRF5

Across TCGA patient cohorts, IRF5 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF5-associated genes across cancer lineages are PI3K-p110-a, Shc_pY317, and ATM. Each is linked with IRF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF5-to-partner and partner-to-IRF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by IRF5-low versus IRF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF5→partner) and Y-score (partner→IRF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p110-a →	-0.131	-1.736	.032	.007	3	2
UCEC	Shc_pY317 →	-0.237	-2.938	<.001	<.001	3	2
UCEC	ATM →	-0.749	-2.459	<.001	<.001	3	2
UCEC	eEF2 →	+0.381	+2.584	.002	.010	3	1
UCEC	EGFR_pY1068 →	-0.262	-2.070	.002	.001	3	1
UCEC	eIF4E →	+0.179	+2.070	.014	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PI3K-p110-a by IRF5 expression — UCEC

Explore this box plot interactively →