IRF5

Across TCGA cell cohorts, IRF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,492 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRF5-associated GO terms across cancer lineages are Cellular response to peptidoglycan, Cytoplasmic pattern recognition receptor signaling pathway, and Negative regulation of NK T cell activation. Each is linked with IRF5 in more than 14 cancer types. Because this analysis shows association rather than direction, both IRF5-to-partner and partner-to-IRF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to peptidoglycan grouped by IRF5-low versus IRF5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF5→partner) and Y-score (partner→IRF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cellular response to peptidoglycan →	-0.334	-1.713	<.001	<.001	3	15
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.068	+2.525	<.001	<.001	3	9
BONE	Negative regulation of NK T cell activation →	+0.911	+0.532	.005	.001	3	9
OVARY	Negative regulation of protein catabolic process →	+0.058	+1.068	.001	.005	3	9
PANCREAS	Protein localization to bicellular tight junction →	+0.132	+1.183	.001	.005	3	8
LUNG_NSCLC_LUAD	T cell mediated immunity →	+0.146	+1.305	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,492 associations by consensus.

Cellular response to peptidoglycan by IRF5 expression — STOMACH

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