IRF4

Across TCGA patient cohorts, IRF4 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,500 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF4-associated proteins across cancer lineages are WAS, WDFY4, and WIPF1. Each is linked with IRF4 in more than 9 cancer types. Because this analysis shows association rather than direction, both IRF4-to-partner and partner-to-IRF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF4 versus WAS in UCEC, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF4→partner) and Y-score (partner→IRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WAS →	+0.585	+1.403	<.001	<.001	3	10
OV	WDFY4 →	+0.646	+1.167	<.001	<.001	3	10
UCEC	WIPF1 →	+0.582	+1.956	<.001	<.001	3	10
GBM	PTPN7 →	+0.679	+0.593	<.001	<.001	3	10
BRCA	PTPRC →	+0.694	+1.370	<.001	<.001	3	10
OV	RAC2 →	+0.840	+0.860	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,500 associations by consensus.

IRF4 vs WAS — UCEC

Explore this scatter interactively →