IRF4

Across TCGA cell cohorts, IRF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,324 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IRF4-associated GO terms across cancer lineages are Nucleocytoplasmic transport, Signal transduction in response to DNA damage, and Nuclear transport. Each is linked with IRF4 in more than 7 cancer types. Because this analysis shows association rather than direction, both IRF4-to-partner and partner-to-IRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleocytoplasmic transport grouped by IRF4-low versus IRF4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF4→partner) and Y-score (partner→IRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nucleocytoplasmic transport →	+0.059	+0.233	.002	.003	3	8
OESOPHAGUS	Signal transduction in response to DNA damage →	+0.061	+0.285	.001	.002	3	8
PANCREAS	Nuclear transport →	+0.059	+0.108	.008	.004	3	8
BREAST	Nuclear export →	+0.073	+0.268	.002	.002	3	7
BREAST	Cytokinesis →	+0.083	+0.245	<.001	.002	3	7
BLOOD_Lymphoma	Positive regulation of cation transmembrane transport →	-0.054	-1.824	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,324 associations by consensus.

Nucleocytoplasmic transport by IRF4 expression — BREAST

Explore this box plot interactively →