IRF4

Across TCGA cell cohorts, IRF4 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRF4-associated genes across cancer lineages are TRIM60, OR1J2, and OR11H2. Each is linked with IRF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF4-to-partner and partner-to-IRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM60 grouped by IRF4-low versus IRF4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF4→partner) and Y-score (partner→IRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRIM60 →	+0.375	+4.930	<.001	.008	3	2
BLOOD_Lymphoma	OR1J2 →	+0.029	+4.192	.001	.003	3	2
BLOOD_Lymphoma	OR11H2 →	+0.021	+3.927	.002	.004	3	2
SOFT_TISSUE	IFNA6 →	+0.030	+5.977	<.001	.001	3	1
SOFT_TISSUE	TEX55 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	GP9 →	+0.026	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

TRIM60 by IRF4 expression — SOFT_TISSUE

Explore this box plot interactively →