IRF3

Across TCGA patient cohorts, IRF3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,206 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IRF3-associated proteins across cancer lineages are NOSIP, PRMT1, and AP2A1. Each is linked with IRF3 in more than 5 cancer types. Because this analysis shows association rather than direction, both IRF3-to-partner and partner-to-IRF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF3 versus NOSIP in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF3→partner) and Y-score (partner→IRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NOSIP →	+0.339	+0.280	<.001	.004	3	6
COAD	PRMT1 →	+0.365	+0.370	<.001	<.001	3	5
BRCA	AP2A1 →	+0.256	+0.740	<.001	<.001	3	5
PDAC	AP2M1 →	+0.261	+0.251	.003	.006	3	4
GBM	ZNF787 →	+0.376	+0.314	<.001	.008	3	4
LUAD	SCAF1_T989 →	+0.510	+0.349	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,206 associations by consensus.

IRF3 vs NOSIP — GBM

Explore this scatter interactively →