IRF3

Across TCGA patient cohorts, IRF3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,237 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF3-associated genes across cancer lineages are SSNA1, PIM2, and BCL2L12. Each is linked with IRF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both IRF3-to-partner and partner-to-IRF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF3 versus SSNA1 in BRCA, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF3→partner) and Y-score (partner→IRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SSNA1 →	-0.650	-0.266	.004	<.001	3	5
CCRCC	PIM2 →	+0.846	+0.233	.001	<.001	3	4
GBM	BCL2L12 →	+0.471	+0.239	.003	.002	3	4
LSCC	INTS14 →	-0.436	-0.220	.001	.003	3	4
BRCA	C1orf56 →	-0.560	-0.234	.001	.008	3	4
OV	IGHG2 →	+2.276	+0.249	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,237 associations by consensus.

IRF3 vs SSNA1 — BRCA

Explore this scatter interactively →