IRF3

Across TCGA patient cohorts, IRF3 mutation is significantly associated with the RNA expression of many other genes, with 450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF3-associated genes across cancer lineages are RNU1-57P, RNU6-55P, and RNU6-493P. Each is linked with IRF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRF3-to-partner and partner-to-IRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-57P grouped by IRF3-low versus IRF3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF3→partner) and Y-score (partner→IRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU1-57P →	+0.963	+7.930	<.001	.008	3	3
LUAD	RNU6-55P →	+1.518	+7.930	<.001	.008	3	3
STAD	RNU6-493P →	+0.680	+4.798	<.001	.006	3	3
READ	MTCO2P34 →	+0.296	+5.925	<.001	.002	3	2
BLCA	ANKRD49P2 →	+0.174	+3.926	.001	.004	3	2
LUAD	MIR383 →	+0.818	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 450 associations by consensus.

RNU1-57P by IRF3 expression — LUAD

Explore this box plot interactively →