IRF3

Across TCGA patient cohorts, IRF3 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF3-associated genes across cancer lineages are Preadipocytes, Adipocytes, and Th2 cells. Each is linked with IRF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF3-to-partner and partner-to-IRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Preadipocytes grouped by IRF3-low versus IRF3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF3→partner) and Y-score (partner→IRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Preadipocytes →	+0.058	+5.169	<.001	<.001	3	2
UCEC	Adipocytes →	+0.023	+3.699	.008	.001	3	2
UCEC	Th2 cells →	+0.299	+2.818	<.001	.035	3	2
LUAD	CD4+ T-cells →	+0.042	+7.930	<.001	.008	3	1
LUSC	CD4+ Tcm →	+0.059	+6.593	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Preadipocytes by IRF3 expression — COAD

Explore this box plot interactively →