IRF3

Across TCGA cell cohorts, IRF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,170 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IRF3-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Negative regulation of RNA splicing, and Regulation of calcium ion export across plasma membrane. Each is linked with IRF3 in more than 11 cancer types. Because this analysis shows association rather than direction, both IRF3-to-partner and partner-to-IRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by IRF3-low versus IRF3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF3→partner) and Y-score (partner→IRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.080	+0.677	.001	<.001	3	12
BONE	Negative regulation of RNA splicing →	+0.095	+0.552	.001	<.001	3	11
BONE	Regulation of calcium ion export across plasma membrane →	+0.083	+0.569	<.001	<.001	3	11
SOFT_TISSUE	Negative regulation of NLRP3 inflammasome complex assembly →	+0.142	+0.797	<.001	<.001	3	10
SOFT_TISSUE	Regulation of pattern recognition receptor signaling pathway →	+0.053	+0.938	<.001	<.001	3	10
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.117	+0.628	.003	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,170 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by IRF3 expression — BONE

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