IRF3

Across TCGA cell cohorts, IRF3 mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRF3-associated genes across cancer lineages are C5orf52, PLA2G3, and GGA1. Each is linked with IRF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF3-to-partner and partner-to-IRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by IRF3-low versus IRF3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF3→partner) and Y-score (partner→IRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C5orf52 →	+0.050	+5.000	<.001	<.001	3	2
LARGE_INTESTINE	PLA2G3 →	+1.052	+3.347	<.001	.005	3	1
LARGE_INTESTINE	GGA1 →	+0.698	+3.364	.001	.002	3	1
LARGE_INTESTINE	EIF3L →	+0.487	+3.067	.007	.009	3	1
LARGE_INTESTINE	CCDC134 →	+0.814	+3.364	.001	.002	3	1
LARGE_INTESTINE	ZBED4 →	+0.670	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

C5orf52 by IRF3 expression — SKIN

Explore this box plot interactively →