IRF2BPL

Across TCGA patient cohorts, IRF2BPL mutation is significantly associated with the RNA expression of many other genes, with 2,910 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2BPL-associated genes across cancer lineages are RNA5SP420, FCGBP, and C17orf98. Each is linked with IRF2BPL in more than 2 cancer types. Because this analysis shows association rather than direction, both IRF2BPL-to-partner and partner-to-IRF2BPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP420 grouped by IRF2BPL-low versus IRF2BPL-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BPL→partner) and Y-score (partner→IRF2BPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP420 →	+0.631	+4.309	<.001	.007	3	3
UCEC	FCGBP →	-1.215	-3.791	<.001	<.001	3	2
UCEC	C17orf98 →	+0.479	+2.782	<.001	<.001	3	2
LUSC	RNU6-1092P →	+0.557	+5.211	<.001	<.001	3	2
ESCA	TSPY24P →	+0.076	+5.068	<.001	.008	3	2
CESC	GYG2P1 →	+0.022	+4.601	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,910 associations by consensus.

RNA5SP420 by IRF2BPL expression — LUSC

Explore this box plot interactively →