IRF2BPL

Across TCGA patient cohorts, IRF2BPL mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2BPL-associated genes across cancer lineages are eIF4E, JNK2, and PKC-delta_pS664. Each is linked with IRF2BPL in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BPL-to-partner and partner-to-IRF2BPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IRF2BPL-low versus IRF2BPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BPL→partner) and Y-score (partner→IRF2BPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.228	+3.087	.007	<.001	3	2
UCEC	JNK2 →	+0.321	+3.486	<.001	.002	3	2
UCEC	PKC-delta_pS664 →	-0.133	-3.321	.006	.009	3	2
UCEC	4E-BP1 →	+0.511	+3.837	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.156	-3.308	.009	.009	3	2
BLCA	GAPDH →	+0.778	+3.000	.001	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by IRF2BPL expression — UCEC

Explore this box plot interactively →