IRF2BPL

Across TCGA cell cohorts, IRF2BPL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,724 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IRF2BPL-associated GO terms across cancer lineages are Negative regulation of transcription initiation by RNA polymerase II, Negative regulation of ubiquitin-dependent protein catabolic process, and Negative regulation of DNA-templated transcription initiation. Each is linked with IRF2BPL in more than 14 cancer types. Because this analysis shows association rather than direction, both IRF2BPL-to-partner and partner-to-IRF2BPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription initiation by RNA polymerase II grouped by IRF2BPL-low versus IRF2BPL-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BPL→partner) and Y-score (partner→IRF2BPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of transcription initiation by RNA polymerase II →	+0.133	+1.326	<.001	<.001	3	15
STOMACH	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.079	+1.185	.005	.004	3	15
PANCREAS	Negative regulation of DNA-templated transcription initiation →	+0.133	+1.326	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	mRNA transcription →	+0.074	+1.144	<.001	<.001	3	14
KIDNEY	Regulation of myoblast fusion →	+0.093	+1.100	.003	.005	3	14
BONE	Negative regulation of myoblast fusion →	+0.121	+1.715	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,724 associations by consensus.

Negative regulation of transcription initiation by RNA polymerase II by IRF2BPL expression — PANCREAS

Explore this box plot interactively →